Unwinding a path to nuclear beta-catenin.
editorial · Level V
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Abstract
In this issue of Cell, Yang et al. (2006b) show that PDGF, a growth factor that induces the transition of epithelial cells to mesenchymal cells, stimulates the c-Abl kinase-dependent phosphorylation of p68 RNA helicase. Phosphorylated p68 dissociates beta-catenin from the Axin destruction complex, thereby promoting nuclear beta-catenin signaling independent of Wnt activation.
Medical subject headings
- Cell Nucleus
- DEAD-box RNA Helicases
- Signal Transduction
- beta Catenin