Effect of donepezil on motor and cognitive function in Huntington disease.
rct · Level II
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- Record sourced from PubMed, PMID 17030764.
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Abstract
Striatal cholinergic dysfunction may be important in Huntington disease (HD). We studied whether donepezil improves chorea, cognition, and quality of life (QoL) in HD. Thirty patients were randomly assigned to treatment with donepezil or placebo. At the doses studied, donepezil did not improve chorea, cognition, or QoL. Adverse events were similar between both groups. Based on this small sample study, donepezil was not an effective treatment for HD.
Medical subject headings
- Chorea
- Cognition Disorders
- Huntington Disease
- Indans
- Piperidines
- Quality of Life
- Recovery of Function