Valproate effects on kinetics of lamotrigine in pregnancy and treatment with oral contraceptives.
prospective_cohort · Level II
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- Record sourced from PubMed, PMID 17030773.
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Abstract
In eight women treated with lamotrigine monotherapy, the lamotrigine dose/plasma concentration (D/C) ratio increased by 295% from baseline outside pregnancy to midgestation, whereas in six women treated with lamotrigine in combination with valproate, the increase was only 60%. No difference in lamotrigine D/C ratio was found between users and nonusers of oral contraceptives comedicated with valproate. Valproate seems to reduce the induction of lamotrigine metabolism associated with pregnancy or use of contraceptives.
Medical subject headings
- Contraceptives, Oral
- Pregnancy
- Triazines
- Valproic Acid