Toward intelligent nanosize bioreactors: a pH-switchable, channel-equipped, functional polymer nanocontainer.
basic_science · Level V
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Abstract
To develop an intelligent sensor-effector functionality on the nanoscale, a pH-switchable, controlled nanoreactor based on amphiphilic copolymer membranes was built. The nanovesicles were equipped with bacterial transmembrane ompF pore proteins and the pH-sensitive enzyme acid phosphatase, resulting in a switchable substrate processing at pH 4-6.5. Ideal pH and substrate concentrations for the reaction were determined experimentally. In future, the reactor might be used for self-regulating targeted diagnostic and therapeutic applications in medicine.
Medical subject headings
- Bioreactors
- Biosensing Techniques
- Nanotechnology
- Polymers
- Porins