THOR: targeted high-throughput ortholog reconstructor.
basic_science · Level V
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- Record sourced from PubMed, PMID 17038343.
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Abstract
Low-coverage genomes (LCGs) are becoming an increasingly important source of data for phylogenetic studies. However, assembly of these genomes is time consuming, difficult and lags behind sequence generation. THOR is a fast, stringent application for targeted reconstruction of sequence orthologs in unassembled LCGs. Using a 4x coverage set of mouse whole-genome sequence reads, THOR could partially or completely reconstruct 416/1000 human promoter ortholog regions in approximately 7.3 min/promoter. THOR's reconstruction rate improves markedly with both higher-coverage, and less divergent target species.
Medical subject headings
- Chromosome Mapping
- Gene Targeting
- Genome, Human
- Sequence Analysis, DNA
- Software