FeMo cofactor maturation on NifEN.
basic_science · Level V
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- Record sourced from PubMed, PMID 17050696.
- Also identified by PMC identifier 1859895.
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Abstract
FeMo cofactor (FeMoco) biosynthesis is one of the most complicated processes in metalloprotein biochemistry. Here we show that Mo and homocitrate are incorporated into the Fe/S core of the FeMoco precursor while it is bound to NifEN and that the resulting fully complemented, FeMoco-like cluster is transformed into a mature FeMoco upon transfer from NifEN to MoFe protein through direct protein-protein interaction. Our findings not only clarify the process of FeMoco maturation, but also provide useful insights into the other facets of nitrogenase chemistry.
Medical subject headings
- Molybdoferredoxin
- Nitrogenase