Bisphosphonates prevent experimental vascular calcification: Treat the bone to cure the vessels?
basic_science · Level V
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Abstract
Bisphosphonates are inhibitors of bone resorption that are widely used to treat osteoporosis. Price and colleagues demonstrate that ibandronate suppressed the development of uremia-related vascular calcification in rats. These findings extend the link between bone remodeling and vascular calcification to the context of chronic renal failure, opening perspectives toward novel therapeutic strategies.
Medical subject headings
- Bone and Bones
- Calcinosis
- Diphosphonates
- Vascular Diseases