The complex route to MHC class I-peptide complexes.
review · Level V
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- Record sourced from PubMed, PMID 17055423.
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Abstract
The loading of peptides into the groove of MHC class I molecules prior to antigen presentation is a complex process. In this issue of Cell, Park et al. (2006) show that peptide loading gets a helping hand from a resident ER enzyme called protein disulfide isomerase, a chaperone that has oxidoreductase activity.
Medical subject headings
- Antigen Presentation
- Histocompatibility Antigens Class I
- Peptides
- Protein Disulfide-Isomerases