Do sigma factors need help with a meltdown?
editorial · Level V
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Abstract
In this issue of Cell, Hsu et al. (2006) report on the binding activity of a variant of the bacterial transcriptional specificity factor sigma (sigma) to promoter DNA. This study demonstrates that the sigma variant induces a large distortion in the transcriptional start site in the absence of core RNA polymerase, raising intriguing new questions about the roles of sigma and core RNA polymerase in transcription initiation.
Medical subject headings
- Bacillus subtilis
- Bacterial Proteins
- Sigma Factor
- Transcription, Genetic