Snaring otoferlin's role in deafness.
review · Level V
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- Record sourced from PubMed, PMID 17055427.
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Abstract
Mutations in the gene encoding otoferlin are known to cause deafness, but the mechanism is unclear. In this issue, Roux et al. (2006) demonstrate that otoferlin interacts with SNARE molecules at the afferent synapses of cochlear inner hair cells to trigger exocytosis of neurotransmitter.
Medical subject headings
- Deafness
- Membrane Proteins
- SNARE Proteins