Keeping transcriptional activators under control.
review · Level V
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- Record sourced from PubMed, PMID 17055428.
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Abstract
Transcriptional activators need to be modulated and eventually switched off after the initial event that triggers their activation. Here, we discuss how ubiquitination of activators and their proteasome-mediated turnover are crucial steps in this process.
Medical subject headings
- Proteasome Endopeptidase Complex
- Protein Processing, Post-Translational
- Trans-Activators
- Transcriptional Activation
- Ubiquitin