Clinicopathologic investigation of a family with expanded SCA8 CTA/CTG repeats.
case_report · Level V
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Abstract
We investigated a family manifesting progressive ataxia, with expanded SCA8 CTA/CTG repeats. Neuropathologically, degeneration of Purkinje, inferior olivary, and nigral neurons and periaqueductal gliosis were evident. The sites of Purkinje cell loss were occupied by fibrillary accumulations. The remaining Purkinje cells showed somatic sprouts, and intracytoplasmic 1C2-positive granular structures were recognizable. This characteristic distribution of neurodegeneration and Purkinje cell cytopathology were distinct from those of other hereditary spinocerebellar ataxias previously reported.
Medical subject headings
- Nerve Tissue Proteins
- Spinocerebellar Ataxias
- Trinucleotide Repeat Expansion