A simulation study of expiratory flow limitation in obstructive patients during mechanical ventilation.

Abstract

Although normal lungs may be represented satisfactorily by symmetrical architecture, pathological conditions generally require accounting for asymmetrical branching of the bronchial tree, since lung heterogeneity may be significant in respiratory diseases. In the present study, a recently proposed symmetrical dynamic morphometric model of the human lung, based on Weibel's regular dichotomy, was adapted to simulate different physiopathological scenarios of lung heterogeneity. The asymmetrical architecture was mimicked by modeling different conductive airway compartments below the main bronchi, each compartment being characterized by regular branching. The respiratory zone and chest wall were described by a Voigt body and a constant elastance, respectively. Simulation results allowed us to investigate the influence of the main mechanisms involved in expiratory flow limitation and dynamic hyperinflation in mechanically ventilated COPD patients. In brief, they showed that convective gas acceleration plays a key role in reproducing a negative relationship between driving pressure and expiratory flow. Moreover, reduced lung elastance due to emphysema resulted in a remarkable increase in dynamic hyperinflation, although it did not significantly modify expiratory flow limitation. Finally, the presence of a normal lung compartment masked pathological behaviors, preventing standard techniques from revealing expiratory flow limitation in affected compartments.