Molecular ablation of ventricular tachycardia after myocardial infarction.
basic_science · Level V
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- Record sourced from PubMed, PMID 17072309.
- Also identified by PMC identifier 1783685.
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Abstract
Ventricular tachycardia is a common and lethal complication after myocardial infarction. Here we show that focal transfer of a gene encoding a dominant-negative version of the KCNH2 potassium channel (KCNH2-G628S) to the infarct scar border eliminated all ventricular arrhythmias in a porcine model. No proarrhythmia or other negative effects were discernable. Our results demonstrate the potential viability of gene therapy for ablation of ventricular arrhythmias.
Medical subject headings
- Myocardial Infarction
- Potassium Channels, Voltage-Gated
- Tachycardia, Ventricular