Modafinil and unconstrained motor activity in schizophrenia: double-blind crossover placebo-controlled trial.
rct · Level II
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- Record sourced from PubMed, PMID 17077439.
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Abstract
Avolition affects quality of life in chronic schizophrenia. We investigated the effect of modafinil upon unconstrained motor activity in 18 male patients. In a randomised crossover design study, wrist-worn actigraphic monitors were used to objectively record motor activity over a 20 h period. Patients' total activity was significantly greater when given the drug. These data suggest that modafinil increases quantifiable motor behaviour in schizophrenia and may have an impact on avolition.
Medical subject headings
- Benzhydryl Compounds
- Central Nervous System Stimulants
- Motor Activity
- Schizophrenia