Adiponectin versus angiotensin II: Key pathological role of their misbalance.

Suzuki, H; Eguchi, S · Kidney Int · 2006

other · Level V

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Abstract

Kurata et al. report that an angiotensin II type-1 receptor blocker (ARB) inhibits obesity-induced hypoadiponectinemia in rats through inhibition of reactive oxygen species generation. Taken together with the recently reported functional interplay between adiponectin and angiotensin II, this suggests that adiponectin probably mediates tissue-protective effects of ARBs in obesity and metabolic syndrome.

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