A mitotic role for BRCA1/BARD1 in tumor suppression?
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 17081965.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
The tumor-suppressor protein BRCA1 is thought to act by preserving genomic integrity. In this issue of Cell, Joukov et al. demonstrate that the BRCA1/BARD1 heterodimer participates in mitotic spindle assembly, a process conducted by the GTPase Ran. Loss of this mitotic function might contribute to tumorigenesis.
Medical subject headings
- BRCA1 Protein
- Spindle Apparatus
- Tumor Suppressor Proteins
- Ubiquitin-Protein Ligases
- ran GTP-Binding Protein