A SUMOry of DNA replication: synthesis, damage, and repair.
basic_science · Level V
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- Record sourced from PubMed, PMID 17081966.
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Abstract
Recombination at stalled replication forks is regulated at an early stage by sumoylation. In this issue of Cell, Branzei et al. show that the Ubc9/SUMO modification pathway controls the accumulation of cruciform structures at stalled forks.
Medical subject headings
- DNA Damage
- DNA Repair
- DNA Replication
- DNA, Fungal
- Ubiquitin-Conjugating Enzymes