Discovering orphans' sweet secret: NR4A receptors and hepatic glucose production.
review · Level V
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Abstract
Aberrant hepatic gluconeogenesis contributes importantly to hyperglycemia in type II diabetic patients. A study by Pei et al. (2006b) identifies NR4A orphan nuclear receptors as a novel branch of cAMP-dependent regulators of hepatic glucose production under healthy and diabetic conditions.
Medical subject headings
- DNA-Binding Proteins
- Diabetes Mellitus, Type 2
- Glucose
- Liver
- Receptors, Cytoplasmic and Nuclear
- Receptors, Steroid
- Transcription Factors