Is the beneficial effect of sulfasalazine due to inhibition of synovial neovascularization?
basic_science · Level V
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Abstract
Angiogenesis is fundamental to support the continued synovial proliferation observed in rheumatoid arthritis. We investigated the effects of sulfasalazine and its metabolites on endothelial cell proliferation, a prerequisite to angiogenesis. At concentrations achieved in vivo sulfapyridine inhibited basal and endothelial cell growth factor stimulated endothelial cell proliferation. Sulfasalazine and 5 amino salicylic acid had no effect.
Medical subject headings
- Arthritis, Rheumatoid
- Sulfasalazine
- Synovial Membrane