Nanoparticles for two-photon photodynamic therapy in living cells.
basic_science · Level V
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- Record sourced from PubMed, PMID 17090062.
- Also identified by PMC identifier 2577608.
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Abstract
We describe here a nontoxic two-photon photodynamic nanoparticle platform and its cellular application. We demonstrate that the dye's potential toxicity can be circumvented by its permanent encapsulation into a biocompatible nanoparticle polymer matrix; this was examined by dye leaching experiments and confirmed by cell uptake experiments. Infrared two-photon nanoplatform phototoxicity was demonstrated for rat C6 glioma cells, while the controls showed no dark toxicity for these living cells.
Medical subject headings
- Nanoparticles
- Photochemotherapy
- Photosensitizing Agents
- Porphyrins