Multifunctional polymeric micelles as cancer-targeted, MRI-ultrasensitive drug delivery systems.
basic_science · Level V
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Abstract
We describe the development of multifunctional polymeric micelles with cancer-targeting capability via alpha(v)beta(3) integrins, controlled drug delivery, and efficient magnetic resonance imaging (MRI) contrast characteristics. Doxorubicin and a cluster of superparamagnetic iron oxide (SPIO) nanoparticles were loaded successfully inside the micelle core. The presence of cRGD on the micelle surface resulted in the cancer-targeted delivery to alpha(v)beta(3)-expressing tumor cells. In vitro MRI and cytotoxicity studies demonstrated the ultrasensitive MRI imaging and alpha(v)beta(3)-specific cytotoxic response of these multifunctional polymeric micelles.
Medical subject headings
- Drug Delivery Systems
- Magnetic Resonance Imaging
- Neoplasms
- Oligopeptides
- Polymers