A scaleable and defined system for generating neural stem cells from human embryonic stem cells.
basic_science · Level V
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Abstract
The ability to differentiate human ESCs (hESCs) to defined lineages in a totally controlled manner is fundamental to developing cell-based therapies and studying human developmental mechanisms. We report a novel, scaleable, and widely applicable system for deriving and propagating neural stem cells from hESCs without the use of animal products, proprietary formulations, or genetic manipulation. This system provides a definitive platform for studying human neural development and has potential therapeutic implications.
Medical subject headings
- Embryonic Stem Cells
- Neurons