Falsely raised TSH levels due to human anti-mouse antibody interfering with thyrotropin assay.
case_report · Level V
Where this comes from
- Record sourced from PubMed, PMID 17099084.
- Also identified by PMC identifier 2660509.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
The case of a 39-year-old woman who was referred for weight gain and amenorrhoea is reported. Laboratory evaluation showed high levels of thyroid-stimulating hormone (TSH). The patient was started on increasing doses of levothyroxine for subclinical hypothyroidism. TSH remained persistently raised and the patient became thyrotoxic. Evaluation at another laboratory showed normal levels of TSH, raising the possibility of interfering substances. TSH levels were normalised with the addition of mouse serum to the patient's sample, confirming the presence of human anti-mouse antibodies as the interfering substance in the TSH assay.
Medical subject headings
- Antibodies, Monoclonal
- Hypothyroidism
- Thyrotropin
- Thyroxine