A randomized, placebo-controlled study of donepezil in poststroke aphasia.

Berthier, M L; Green, C; Higueras, C; Fernández, I; Hinojosa, J; Martín, M C · Neurology · 2006

rct · Level II

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Abstract

We studied 26 patients in a randomized, placebo-controlled, double-blind parallel trial to evaluate the efficacy and safety of donepezil in chronic poststroke aphasia. Donepezil (10 mg/day) improved aphasia severity at endpoint (week 16) relative to placebo (p = 0.037).

Medical subject headings