Immune reconstitution inflammatory syndrome associated with PML in AIDS: a treatable disorder.
case_report · Level V
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Abstract
An HIV-1-infected patient with progressive multifocal leukoencephalopathy presented clinical deterioration and contrast-enhancing lesions on brain nuclear MR after the initiation of highly active antiretroviral therapy (HAART). Brain biopsy identified an inflammatory reaction compatible with immune reconstitution inflammatory syndrome. Treatment with corticosteroids and transient suppression of HAART led to marked neurologic improvement.
Medical subject headings
- Acquired Immunodeficiency Syndrome
- Antiretroviral Therapy, Highly Active
- Brain
- Encephalitis
- Leukoencephalopathy, Progressive Multifocal