Variation of the serotonin transporter gene SLC6A4 in the susceptibility to migraine with aura.
case_control · Level III
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Abstract
To replicate a reported association between migraine with aura (MA) and a promoter polymorphism in the serotonin transporter gene (SLC6A4), we performed a case-control study in a large German sample comprising 472 patients with MA and 506 controls. Neither this polymorphism nor a systematic analysis with single nucleotide polymorphisms capturing the main haplotype diversity of the SLC6A4 locus provided evidence for a contribution of SLC6A4 to the predisposition of complex inherited MA.
Medical subject headings
- Genetic Predisposition to Disease
- Migraine with Aura
- Polymorphism, Genetic
- Serotonin
- Serotonin Plasma Membrane Transport Proteins