A causal role for the human tumor antigen preferentially expressed antigen of melanoma in cancer.
review · Level V
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Abstract
Tumor antigens are of interest as diagnostic and prognostic markers and potential therapeutic targets. The tumor antigen preferentially expressed antigen of melanoma (PRAME) is frequently overexpressed in a wide variety of cancers and is a prognostic marker for clinical outcome. It has been shown recently that PRAME functions as a repressor of retinoic acid signaling. Here, we discuss this novel insight in the context of the increasing interest in tumor antigens as targets for therapy.
Medical subject headings
- Antigens, Neoplasm
- Neoplasms