Blinded case-control study of the relationship between human coronavirus NL63 and Kawasaki syndrome.
case_control · Level III
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- Record sourced from PubMed, PMID 17109341.
- Also identified by PMC identifier 7199878.
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Abstract
We conducted a blinded, case-control, retrospective study in pediatric patients hospitalized at The Children's Hospital, Denver, Colorado, to determine whether human coronavirus (HCoV)-NL63 infection is associated with Kawasaki syndrome (KS). Over the course of a 7-month period, nasopharyngeal-wash samples from 2 (7.7%) of 26 consecutive children with KS and 4 (7.7%) of 52 matched control subjects tested positive for HCoV-NL63 by reverse transcription-polymerase chain reaction. These data suggest that, although HCoV-NL63 was circulating in children in our community during the time of the study, the prevalence of infection with HCoV-NL63 was not greater in patients with KS than in control subjects.
Medical subject headings
- Coronavirus
- Coronavirus Infections
- Mucocutaneous Lymph Node Syndrome