A new function for p53 ubiquitination.
editorial · Level V
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Abstract
The amount of p53 protein in a cell is normally limited by ubiquitin-dependent degradation. In this issue of Cell, Le Cam et al. (2006) reveal that p53 ubiquitination contributes to transcriptional activation rather than protein stability. These results may provide insight into how p53 can modulate diverse cellular processes such as growth arrest and apoptosis.
Medical subject headings
- Tumor Suppressor Protein p53
- Ubiquitin-Protein Ligases