Manic behaviour induced by deep-brain stimulation in Parkinson's disease: evidence of substantia nigra implication?
case_report · Level V
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- Record sourced from PubMed, PMID 17110749.
- Also identified by PMC identifier 2077423.
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Abstract
We report the case of a patient who had benefited from bilateral subthalamic nucleus deep brain stimulation for Parkinson's disease and who presented acute and reproducible manic behaviour when stimulated mainly in the substantia nigra. A positron emission tomography scan showed an activation of the right dorsolateral prefrontal and inferior temporal cortex, the left anterior cingulate cortex and a deactivation of the left insula. This suggests that changes in cortical activation related to mania are subcortically driven, involving notably the substantia nigra.
Medical subject headings
- Bipolar Disorder
- Deep Brain Stimulation
- Parkinson Disease
- Substantia Nigra