Immunomodulators interfere with angiopathy but not vasospasm after subarachnoid haemorrhage in rabbits.
basic_science · Level V
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Abstract
The present study deals with the effects of immunomodulators on the morphology of intracerebral arterial walls in rabbits with experimental subarachnoid haemorrhage (SAH). Immunostimulators:thymostimuline and inosine dimethylamino-isopropanol-p-acetamido-benzoate were found to aggravate the angiopathic changes, whereas immunosuppressive drugs-cyclosporine A and azathioprine appeared to prevent the damage. The authors consider the possibility of using immunosuppressive drugs in patients with ruptured intracranial aneurysms.
Medical subject headings
- Azathioprine
- Cerebral Arteries
- Cyclosporins
- Muscle, Smooth, Vascular
- Subarachnoid Hemorrhage