Activation of an oncogenic microRNA cistron by provirus integration.
basic_science · Level V
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- Record sourced from PubMed, PMID 17121985.
- Also identified by PMC identifier 1693722.
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Abstract
Retroviruses can cause tumors when they integrate near a protooncogene or tumor suppressor gene of the host. We infected >2,500 mice with the SL3-3 murine leukemia virus; in 22 resulting tumors, we found provirus integrations nearby or within the gene that contains the mir-17-92 microRNA (miRNA) cistron. Using quantitative real-time PCR, we showed that expression of miRNA was increased in these tumors, indicating that retroviral infection can induce expression of oncogenic miRNAs. Our results demonstrate that retroviral mutagenesis can be a potent tool for miRNA discovery.
Medical subject headings
- Leukemia Virus, Murine
- MicroRNAs
- Oncogenes
- Proviruses
- RNA, Neoplasm
- RNA, Viral
- Virus Integration