CD62 and endothelial cell-leukocyte adhesion molecule 1 (ELAM-1) recognize the same carbohydrate ligand, sialyl-Lewis x.
basic_science · Level V
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- Record sourced from PubMed, PMID 1712483.
- Also identified by PMC identifier 52055.
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Abstract
The leukocyte receptor CD62, which is expressed on activated platelets and endothelial cells, is shown to mediate cell adhesion by binding a sialylated carbohydrate structure, sialyl-Lewis x, found on neutrophils, monocytes, and tumor cells. This structure has previously been identified as the ligand for another member of the LEC-CAM family of cell adhesion molecules, endothelial cell-leukocyte adhesion molecule 1, which also binds neutrophils and monocytes. The results demonstrate that although the two LEC-CAMs differ in their biological activities by their distribution and mode of expression, they are capable of mediating cell adhesion by recognition of the same carbohydrate ligand.
Medical subject headings
- Blood Platelets
- Cell Adhesion
- Cell Adhesion Molecules
- Endothelium, Vascular
- Lewis X Antigen
- Neutrophils
- Platelet Membrane Glycoproteins