Reduction of optic nerve fibers in patients with Alzheimer disease identified by laser imaging.
case_control · Level III
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Abstract
In this case-control study, we compared the optic nerves (ONs) by clinical examination and scanning laser ophthalmoscopy (SLO) of 40 patients with Alzheimer disease (AD) and 50 controls. There was a reduction in the number of ON fibers in patients with AD, with a threefold greater odds ratio for a larger optic cup-to-disc ratio in patients with AD.
Medical subject headings
- Alzheimer Disease
- Microscopy, Confocal
- Optic Nerve
- Optic Nerve Diseases