Strong genetic evidence for association of TOR1A/TOR1B with idiopathic dystonia.
case_control · Level III
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Abstract
Recently, association of a TOR1A(DYT1)/TOR1B risk haplotype with common forms of idiopathic dystonia has been reported in the Icelandic population. Here we report a strong association of two single nucleotide polymorphisms within or in close proximity to the TOR1A 3'UTR, with the lowest p value being 0.000008, in a larger cohort of German and Austrian patients with predominantly focal sporadic dystonia.
Medical subject headings
- Brain Chemistry
- Dystonic Disorders
- Genetic Predisposition to Disease
- Molecular Chaperones
- Polymorphism, Single Nucleotide