Increased farnesylation of p21-Ras and neonatal macrosomia in women with gestational diabetes.
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Abstract
Six of 22 mothers with gestational diabetes mellitus had infants with macrosomia, cord blood hyperinsulinemia, and increased amounts of a key mitogenic intermediate, farnesylated p21-Ras. The ability of fetal hyperinsulinemia to increase the availability of farnesylated p21-Ras may represent one mechanism of the growth-promoting action of insulin during fetal development.
Medical subject headings
- Diabetes, Gestational
- Fetal Blood
- Fetal Macrosomia
- Insulin
- Leukocytes
- Protein Prenylation
- Proto-Oncogene Proteins p21(ras)