Fat uses a TOLL-road to connect inflammation and diabetes.
review · Level V
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- Record sourced from PubMed, PMID 17141623.
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Abstract
The link between inflammation and diabetes is well established, but the nature of the link is unresolved. Obesity, inflammation, and insulin resistance are major characteristics of diabetes. A study by Flier and colleagues () identifies Toll-like receptor 4 signaling activated by fatty acids as part of that link. This receptor mediates inflammatory events and insulin resistance in peripheral organs.
Medical subject headings
- Diabetes Mellitus
- Fatty Acids
- Insulin Resistance
- Obesity
- Toll-Like Receptor 4