Tomographic molecular imaging and 3D quantification within adult mouse organs.
basic_science · Level V
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Abstract
A convenient technology to quantify three-dimensional (3D) morphological features would have widespread applications in biomedical research. Based on combined improvements in sample preparation, tomographic imaging and computational processing, we present a procedure for high-resolution 3D quantification of structures within intact adult mouse organs. Using the nonobese diabetic (NOD) mouse model, we demonstrate a correlation between total islet beta-cell volume and the onset of type-1 diabetes.
Medical subject headings
- Diabetes Mellitus, Type 1
- Image Processing, Computer-Assisted
- Imaging, Three-Dimensional
- Islets of Langerhans
- Pancreas
- Tomography