No improvement of posttraumatic stress disorder symptoms with guanfacine treatment.
rct · Level II
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Abstract
The authors report an 8-week, double-blind, randomized controlled trial of guanfacine versus placebo for posttraumatic stress disorder (PTSD). Veterans with chronic PTSD who were medication-free or receiving stable pharmacotherapy were randomly assigned to guanfacine (N=29) versus placebo (N=34). Guanfacine had no effect on PTSD symptoms, subjective sleep quality, or general mood disturbances. Guanfacine was associated with a number of side effects. These results do not support the use of alpha 2 agonists in veterans with chronic PTSD.
Medical subject headings
- Adrenergic alpha-Agonists
- Guanfacine
- Stress Disorders, Post-Traumatic