High seroprevalence of Epstein-Barr virus in children with multiple sclerosis.
case_control · Level III
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Abstract
We studied seroprevalence and concentrations of Epstein-Barr virus (EBV) antibodies in 147 pediatric patients with multiple sclerosis (MS) and paired controls. The children with MS showed a near-complete seropositivity for EBV antibody against virus capsid antigen (98.6% vs 72.1% in controls, p = 0.001) but did not display serologic evidence for a recent EBV infection. EBV antibody concentrations of pediatric patients with MS were significantly higher vs controls.
Medical subject headings
- Herpesvirus 4, Human
- Multiple Sclerosis