In vino veritas: a tale of two sirt1s?
review · Level V
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- Record sourced from PubMed, PMID 17174885.
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Abstract
Resveratrol increases life span in lower organisms by activating the NAD(+)-dependent histone deacetylase Sirt1. Studies by and now show that resveratrol promotes longevity and improves glucose homeostasis in mice by stimulating the Sirt1-mediated deacetylation of the transcriptional coactivator PGC-1alpha.
Medical subject headings
- Longevity
- Sirtuins
- Stilbenes
- Trans-Activators