A view to a kill: structure of the RNA exosome.
basic_science · Level V
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- Record sourced from PubMed, PMID 17174886.
- Also identified by PMC identifier 1986773.
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Abstract
The exosome is a 3' to 5' exoribonuclease central to many cellular processes, including mRNA decay. now present the biochemical reconstitution and crystal structure of the eukaryotic exosome. This remarkable achievement provides key insights into the composition and assembly of the human and yeast exosomes, revealing functions of individual subunits.
Medical subject headings
- Exoribonucleases
- RNA Stability