Sensory neurons link the nervous system and autoimmune diabetes.
basic_science · Level V
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Abstract
The initial factors that trigger the autoimmune response against pancreatic islets in the nonobese diabetic (NOD) mouse are still unknown. In this issue of Cell, propose that a defect in a subset of sensory neurons innervating the pancreas plays a major role in initiating the chain of events that will lead to local inflammation, islet destruction, and autoimmune diabetes.
Medical subject headings
- Diabetes Mellitus, Type 1
- Islets of Langerhans
- Neurons, Afferent