A receptor tyrosine kinase cDNA isolated from a population of enriched primitive hematopoietic cells and exhibiting close genetic linkage to c-kit.
basic_science · Level V
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- Record sourced from PubMed, PMID 1717995.
- Also identified by PMC identifier 52644.
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Abstract
We have cloned a receptor tyrosine kinase cDNA, designated fetal liver kinase 1 (Flk-1), from mouse cell populations enriched for hematopoietic stem and progenitor cells. Sequence analysis of this clone reveals strong homology to the c-Kit subfamily of receptor kinases, and in particular to the Flt gene product. Chromosomal mapping shows that the Flk-1, Kit, and Pdgfra genes are closely linked. Flk-1 mRNA is expressed in primitive and more mature hematopoietic cells as well as in a wide variety of nonhematopoietic tissues.
Medical subject headings
- DNA
- Genetic Linkage
- Hematopoietic Stem Cells
- Protein-Tyrosine Kinases
- Proto-Oncogene Proteins
- Proto-Oncogenes
- Receptors, Cell Surface