Angiotensin in the kidney: a key to understanding hypertension?
basic_science · Level V
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- Record sourced from PubMed, PMID 17189202.
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Abstract
A crosstransplantation study between genetically matched angiotensin AT1 receptor knockout and wild-type mice revealed that renal AT1 receptors are required for the development of angiotensin II-induced hypertension (). However, in this experimental setting, hypertension-related left ventricular hypertrophy seemed to depend on blood pressure elevation rather than on the expression of AT1 receptors in the heart.
Medical subject headings
- Angiotensin II
- Hypertension
- Kidney