Hosting neurotoxicity in polyglutamine disease.
review · Level V
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- Record sourced from PubMed, PMID 17190592.
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Abstract
Polyglutamine diseases are caused by an expanded glutamine domain thought to confer a toxic activity onto the respective disease proteins. In this issue, propose that toxicity of the polyglutamine protein Ataxin-1 may not be due to abberant protein interactions mediated by the polyglutamine expansion. Instead, they suggest that toxicity is solely due to interactions of Ataxin-1 with its normal binding partners.
Medical subject headings
- Nerve Tissue Proteins
- Neurodegenerative Diseases
- Nuclear Proteins
- Peptides
- Repressor Proteins
- Spinocerebellar Ataxias