Keeping the noise down in ES cells.
basic_science · Level V
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Abstract
A new report (Szutorisz et al., 2006) suggests that embryonic stem (ES) cells adopt an unusual strategy to remain perpetually poised for differentiation. Apparently, ES cells use the proteasome to target transcriptional preinitiation complexes, thus minimizing transcriptional noise at genes that promote differentiation.
Medical subject headings
- Embryonic Stem Cells
- Proteasome Endopeptidase Complex
- Transcription Factors
- Transcription, Genetic