Retrograde control of neural circuit formation.
basic_science · Level V
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- Record sourced from PubMed, PMID 17190596.
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Abstract
Glial-derived neurotrophic factor (GDNF), secreted by skeletal muscle, triggers expression of the ETS transcription factor Pea3 in a subset of motor neurons in the spinal cord. In this issue, find that this retrograde GDNF-Pea3 signal controls dendrite patterning and assembly of a sensory-motor reflex circuit.
Medical subject headings
- Dendrites
- Motor Neurons
- Spinal Cord
- Transcription Factors