Optical and magnetic resonance imaging of cell death and platelet activation using annexin a5-functionalized quantum dots.
basic_science · Level V
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Abstract
A quantum-dot-based nanoparticle is presented, allowing visualization of cell death and activated platelets with fluorescence imaging and MRI. The particle exhibits intense fluorescence and a large MR relaxivity (r1) of 3000-4500 mM-1 s-1 per nanoparticle due to a newly designed construct increasing the gadolinium-DTPA load. The nanoparticle is suitable for both anatomic and subcellular imaging of structures in the vessel wall and is a promising bimodal contrast agent for future in vivo imaging studies.
Medical subject headings
- Annexin A5
- Cell Death
- Magnetic Resonance Imaging
- Platelet Activation
- Quantum Theory